Related Publications

Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adults

Ogwang C, Kimani D, Edwards NJ, Roberts R, Mwacharo J, Bowyer G, Bliss C, Hodgson SH, Njuguna P, Viebig NK, Nicosia A, Gitau E, Douglas S, Illingworth J, Marsh K, Lawrie A, Imoukhuede EB, Ewer K, Urban BC, Hill AVS, Bejon P, MVVC Group.

Science Translational Medicine. May 2015. doi: 10.1126/scitranslmed.aaa2373

 

A Monovalent Chimpanzee Adenovirus Ebola Vaccine - Preliminary Report.

Rampling T, Ewer K, Bowyer G, Wright D, Imoukhuede EB, Payne R, Hartnell F, Gibani M, Bliss C, Minhinnick A, Wilkie M, Venkatraman N, Poulton I, Lella N, Roberts R, Sierra-Davidson K, Krahling V, Berrie E, Roman F, De Ryck I, Nicosia A, Sullivan NJ, Stanley DA, Ledgerwood JE, Schwartz RM, Siani L, Colloca S, Folgori A, Di Marco S, Cortese R, Becker S, Graham BS, Koup RA, Levine MM, Moorthy V, Pollard AJ, Draper SJ, Ballou WR, Lawrie A, Gilbert SC, Hill AV.

New England Journal of Medicine. January 2015. doi: 10.1056/NEJMoa1411627

 

A Phase Ia Study to Assess the Safety and Immunogenicity of New Malaria Vaccine Candidates ChAd63 CS Administered Alone and with MVA CS.

de Barra E, Hodgson SH, Ewer KJ, Bliss CM, Hennigan K, Collins A, Berrie E, Lawrie AM, Gilbert SC, Nicosia A, McConkey SJ, Hill AV.

PLoS ONE. December 2014. doi: 10.1371/journal.pone.0115161

 

Evaluation of the Efficacy of ChAd63-MVA Vectored Vaccines Expressing CS & ME-TRAP Against Controlled Human Malaria Infection in Malaria Naïve Individuals.

Hodgson SH, Ewer KJ, Bliss CM, Edwards NJ, Rampling T, Anagnostou NA, de Barra E, Havelock T, Bowyer G, Poulton ID, de Cassan S, Illingworth JJ, Douglas AD, Mange PB, Collins KA, Roberts R, Gerry S, Berrie E, Moyle S, Colloca S, Cortese R, Sinden RE, Gilbert SC, Bejon P, Lawrie AM, Nicosia A, Faust SN, Hill AV.

Journal of Infectious Diseases. October 2014. doi: 10.1093/infdis/jiu579

 

Safety and tolerability of conserved region vaccines vectored by plasmid DNA, simian adenovirus and modified vaccinia virus ankara administered to human immunodeficiency virus type 1-uninfected adults in a randomized, single-blind phase I trial.

Hayton EJ, Rose A, Ibrahimsa U, Del Sorbo M, Capone S, Crook A, Black AP, Dorrell L, Hanke T.

PLOS ONE. July 2014. doi: 10.1371/journal.pone.0101591

 

Translating the immunogenicity of prime-boost immunisation with ChAd63 and MVA ME-TRAP from malaria naïve to malaria-endemic populations.

Kimani D, Jagne YJ, Cox M, Kimani E, Bliss CM, Gitau E, Ogwang C, Afolabi MO, Bowyer G, Collins KA, Edwards N, Hodgson SH, Duncan CJ, Spencer AJ, Knight MG, Drammeh A, Anagnostou NA, Berrie E, Moyle S, Gilbert SC, Soipei P, Okebe J, Colloca S, Cortese R, Viebig NK, Roberts R, Lawrie AM, Nicosia A, Imoukhuede EB, Bejon P, Chilengi R, Bojang K, Flanagan KL, Hill AV, Urban BC, Ewer KJ.

Molecular Therapy. June 2014. doi: 10.1038/mt.2014.109

 

Analysis of human B-cell responses following ChAd63-MVA MSP1 and AMA1 immunization and controlled malaria infection.

Elias SC, Choudhary P, de Cassan SC, Biswas S, Collins KA, Halstead FD, Bliss CM, Ewer KJ, Hodgson SH, Duncan CJA, Hill AVS, Draper SJ.

Immunology. Apr 2014. doi: 10.1111/imm.12226

 

Vaccine-elicited Human T Cells Recognizing Conserved Protein Regions Inhibit HIV-1

Borthwick N, Ahmed T, Ondondo B, Hayes P, Rose A, Ebrahimsa U, Hayton EJ, Black A, Bridgeman A, Rosario M, Hill AVS, Berrie E, Moyle S, Frahm N, Cox J, Colloca S, Nicosia A, Gilmour J, McMichael AJ, Dorrell L, Hanke T.

Molecular Therapy. Jan 2014, doi:10.1038/mt.2013.248

 

Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial

Clinical Assessment of a Novel Recombinant Simian Adenovirus ChAdOx1 as a Vectored Vaccine Expressing Conserved Influenza A Antigens.

Antrobus RD, Coughlan L, Berthoud TK, Dicks MD, Hill AVS, Lambe T, Gilbert SC.

Molecular Therapy. Dec 2013, doi: 10.1038/mt.2013.284
 
 

Antrobus RD, Berthoud TK, Mullarkey CE, Hoschler K, Coughlan L, Zambon M, Hill AVS, Gilbert SC.

Molecular Therapy. Jul 2013, doi: 10.1038/mt.2013.162

 

Safety and immunogenicity of heterologous prime-boost immunisation with Plasmodium falciparum malaria candidate vaccines, ChAd63 ME-TRAP and MVA ME-TRAP, in healthy Gambian and Kenyan adults.

Ogwang C, Afolabi M, Kimani D, Jagne YJ, Sheehy SH, Bliss CM, Duncan CJ, Collins KA, Garcia Knight MA, Kimani E, Anagnostou NA, Berrie E, Moyle S, Gilbert SC, Spencer AJ, Soipei P, Mueller J, Okebe J, Colloca S, Cortese R, Viebig NK, Roberts R, Gantlett K, Lawrie AM, Nicosia A, Imoukhuede EB, Bejon P, Urban BC, Flanagan KL, Ewer KJ, Chilengi R, Hill AV, Bojang K.

PLoS One. 2013; 8 (3):e57726. doi: 10.1371

 

ChAd63-MVA–vectored Blood-stage Malaria Vaccines Targeting MSP1 and AMA1: Assessment of Efficacy Against Mosquito Bite Challenge in Humans

Susanne H Sheehy, Christopher JA Duncan, Sean C Elias, Prateek Choudhary, Sumi Biswas, Fenella D Halstead, Katharine A Collins, Nick J Edwards, Alexander D Douglas, Nicholas A Anagnostou, Katie J Ewer, Tom Havelock, Tabitha Mahungu, Carly M Bliss, Kazutoyo Miura, Ian D Poulton, Patrick J Lillie, Richard D Antrobus, Eleanor Berrie, Sarah Moyle, Katherine Gantlett, Stefano Colloca, Riccardo Cortese, Carole A Long, Robert E Sinden, Sarah C Gilbert, Alison M Lawrie, Tom Doherty, Saul N Faust, Alfredo Nicosia, Adrian VS Hill and Simon J Draper

Molecular Therapy (2012); 20 (12), 2355–2368. doi:10.1038/mt.2012.223

 

Novel Adenovirus-Based Vaccines Induce Broad and Sustained T Cell Responses to HCV in Man.

Eleanor Barnes, Antonella Folgori, Stefania Capone, Leo Swadling, Stephen Aston, Ayako Kurioka, Joel meyer, Rachel Hudddart, Kira Smith, Rachel Townsend, Anthony Brown, Richard Antrobus, Virginia Ammendola, Mariarosaria Naddeo, Geraldine O'Hara, Chris Willberg, Abby Harrison, Fabiana Grazioli, Maria L Esposito, Loredana Siani, Cinzia Traboni, Ye Oo, David Adams, Adrian Hill, Stefano Colloca, Alfredo Nicosia, Riccardo Cortese, Paul Klenerman.

Scientific Translational Medicine (Jan 2012); 4 (115), p.115ra1. doi:10.1126/scitranslmed.3003155

 

Phase Ia Clinical Evaluation of the Plasmodium falciparum Blood-stage Antigen MSP1 in ChAd63 and MVA Vaccine Vectors

Susanne H Sheehy, Christopher JA Duncan, Sean C Elias, Katharine A Collins, Katie J Ewer, Alexandra J Spencer, Andrew R Williams, Fenella D Halstead, Samuel E Moretz, Kazutoyo Miura, Christian Epp, Matthew DJ Dicks, Ian D Poulton, Alison M Lawrie, Eleanor Berrie, Sarah Moyle, Carole A Long, Stefano Colloca, Riccardo Cortese, Sarah C Gilbert, Alfredo Nicosia, Adrian VS Hill and Simon J Draper

Molecular Therapy (2011); doi:10.1038/mt.2011.176

 

Viruses as vaccine vectors for infectious diseases and cancer.

Draper SJ, Heeney JL.

Nature Reviews Microbiology 2010 Jan;8(1):62-73.

 

Prime-boost immunization with adenoviral and modified vaccinia virus ankara vectors enhances the durability and polyfunctionality of protective malaria CD8+ T-cell responses.

Reyes-Sandoval A, Berthoud T, Alder N, Siani L, Gilbert SC, Nicosia A, Colloca S, Cortese R, Hill AV.

Infection and Immunity 2010 Jan;78(1):145-53. Epub 2009 Oct 26.

 

Prime-boost vectored malaria vaccines: Progress and prospects.

Hill AV, Reyes-Sandoval A, O'Hara G, Ewer K, Lawrie A, Goodman A, Nicosia A, Folgori A, Colloca S, Cortese R, Gilbert SC, Draper SJ.

Human Vaccines 2010 Jan 18;6(1).

 

Effective induction of high-titer antibodies by viral vector vaccines.

Draper SJ, Moore AC, Goodman AL, Long CA, Holder AA, Gilbert SC, Hill F, Hill AV.

Nature Medicine 2008 Aug;14(8):819-21. Epub 2008 Jul 27.

 

Turning Monoclonal Antibodies into Adenoviral Vectors - An Academic Perspective.

E.L. Berrie; E.J. Bolam; P. Bird; L. Andrews; P.A. Gallagher; C.A. Oliveira; P.G. Triggs and S.P. Moyle